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Author Topic: Immunodeficiency Disorders  (Read 307 times)

Demisam

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Immunodeficiency Disorders
« on: March 20, 2018, 12:53:06 pm »
Immunodeficiency Disorders

What Is an Immunodeficiency Disorder?

Immunodeficiency disorders prevent your body from being able to fight infections and diseases the way it should. An immunodeficiency disorder makes you considerably more susceptible to catching viruses and bacterial infections.

Immune disorders are oftentimes categorized as either congenital or acquired. When you’re born with a disorder, it’s sometimes called a congenital or primary disorder. Acquired disorders are sometimes called secondary disorders. Secondary disorders are more common than primary (UpToDate, 2012).

How Does the Immune System Work?

To understand immune disorders, you need to understand the basics of how your immune system works. The immune system is made up of several organs including your spleen, tonsils, bone marrow, and lymph nodes. These organs make and release lymphocytes, which are white blood cells classified as B cells and T cells. B and T cells fight invaders called antigens. Examples of antigens are bacteria, viruses, cancer cells, or bodily fluids from a sick person. B cells release antibodies specific to the disease your body detects. T cells kill off the cells in your body that are being attacked by disease.

What Are the Different Types of Immunodeficiency Disorders?

Primary immunodeficiency disorders are immune disorders you are born with. Primary disorders include:

X-linked agammaglobulinemia (XLA)
severe combined immunodeficiency (SCID disorders)
common variable immunodeficiency
Alymphocytosis (“boy in a bubble” disease)
Secondary disorders happen when your body is attacked by an outside source, such as a toxic chemical or an infection. Severe burns and radiation also can cause secondary disorders. Secondary disorders include:

AIDS
cancers of the immune system, such as leukemia
immune complex diseases, such as viral hepatitis
multiple myeloma
Who Is at Risk For Immunodeficiency Disorders?

People who have a family history of primary disorders are at a higher-than-normal risk for them.

Anything that weakens your immune system can lead to a secondary immunodeficiency disorder. For example, the exposure to bodily fluids such as blood and sperm from someone infected with HIV can cause AIDS.

Removing the spleen can weaken your immune system. Spleen removal may be required in response to one of any number of diseases or injuries, including cirrhosis of the liver, sickle cell anemia, or trauma to the spleen. Aging also weakens your immune system. As you age, some of the organs that produce white blood cells shrink and produce fewer of them.

Proteins are important to your immunity. An insufficient amount of protein in the diet can reduce the strength of your immune system. Additionally, when you sleep, your body produces proteins that help your immune system fight infection. For this reason, lack of sleep reduces your immune defenses.

Cancers and the chemotherapy drugs used to treat them can reduce your immunity.

The following diseases and conditions are also linked to immunodeficiency disorders:

ataxia-telangiectasia
Chediak-Higashi syndrome
combined immunodeficiency disease
complement deficiencies
DiGeorge syndrome
hypogammaglobulinemia
Job syndrome
leukocyte adhesion defects
panhypogammaglobulinemia
Bruton’s disease
congenital agammaglobulinemia
selective deficiency of IgA
Wiskott-Aldrich syndrome
How Are Immune Disorders Diagnosed?

If your doctor thinks you might have an immunodeficiency disorder, he or she will want to do a thorough medical exam including:

medical history
physical exam
T cell count
white blood cell count
Vaccines can be used to test your immune system response in what is called an antibody test. Your doctor will give you a vaccine and make an appointment in a few days or weeks to test your blood for its response to the vaccine. If you don’t have an immunodeficiency disorder, your immune system will produce antibodies to fight the organisms in the vaccine. You might have a disorder if your blood test doesn’t show antibodies.

How Are Immunodeficiency Disorders Treated?

Each disorder will be treated according to the specific conditions it causes. For example, AIDS causes several different infections, including Kaposi’s sarcoma, which is treated with doxorubicin lipid complex, and cryptococcosis, which is treated with fluconazole.

Treatment for immunodeficiency disorders commonly includes antibiotics and antibody replacement. A drug called interferon is often used to treat the viral infections caused by a disorder.

If your bone marrow is not producing enough lymphocytes, your doctor might order a bone marrow transplant.

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